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During March and April, the security and epidemic situation in Burkina Faso remained worrying. The humanitarian situation was marked by increasing attacks and population displacements reported in several localities, with ten alerts shared by rapid response teams reporting thousands of displacements. The latest figures for internally displaced persons (IDPs), published on April 22, 2020, show 848,329 IDPs. An increase in the number of incidents – a total of 268 for the two months of March and April 3 – involving humanitarian actors and resulting in the loss of goods and materials. Attacks and threats on the population have had repercussions on the healthcare system, forcing the displacement of healthcare staff who were also directly targeted by armed groups; healthcare staff have been threatened and intimidated, sometimes resulting in the closure of health facilities due to the departure of healthcare staff and often anticipating displacement out of psychosis, like the general population. Burkina Faso is experiencing unprecedented complex outbreaks of polio, measles and COVID-19, with high incidence and case-fatality rates. With multiple endemo-epidemic diseases such as malaria, dengue fever, measles, meningitis, etc., COVID-19 has also been added to the list. COVID-19 is an emerging epidemic disease first discovered in China in early December 2019, COVID-19 has severely affected the population of Burkina Faso and shaken its healthcare system, which is also weakened by conflict in addition to structural deficits.