The architecture of universal health coverage can be defined as a coherent set of mechanisms or instruments for pooling and managing funds to enable the collective assumption of expenses linked to people’s access to health care and services. These mechanisms include social insurance, social mutuals, national programs for free access to health care and services, private health insurance and social economy structures. Several of these mechanisms already exist in Cameroon, but they operate in a fragmented way and have very little impact. The major concern is how to specialize each of these mechanisms according to its comparative advantage, and how to link them together to create a coherent system. This note presents the organizational and technical characteristics of the architecture scenarios for the universal health coverage system in Cameroon.