“The Potential Cost-Effectiveness of HPV Vaccination Among Girls in Mongolia”<\/a> , <\/em>HPV vaccination has not been introduced nationally and Gavi co-financing support is not available in Mongolia. To inform introduction decision-making, study authors evaluated the potential cost-effectiveness of HPV vaccination among girls and young women in Mongolia. <\/strong><\/p>\nKey findings:<\/strong><\/p>\n\n- Cervical Cancer Burden<\/strong>: Mongolia has an age-standardized incidence rate of 23.5 per 100,000 women<\/strong> and an age-standardized mortality rate of 10.2 per 100,000 women<\/strong>.<\/li>\n
- HPV Vaccination Impact<\/strong>:\n
\n- Expected to avert 5,692 cervical cancer cases<\/strong> and 3,240 deaths<\/strong> over ten birth cohorts.<\/li>\n
- Reduces the burden by 11,886 disability-adjusted life years (DALYs)<\/strong>.<\/li>\n<\/ul>\n<\/li>\n
- Cost Considerations<\/strong>:\n
\n- At a vaccine price of $4.50\u2013$4.60 per dose<\/strong>, the incremental cost-effectiveness ratio (ICER)<\/strong> is $166\u2013$265 per DALY averted<\/strong>.<\/li>\n
- If the price increases to $14.17 per dose<\/strong>, the ICER rises to $556\u2013$820 per DALY averted<\/strong>.<\/li>\n<\/ul>\n<\/li>\n
- Comparative Cost-Effectiveness<\/strong>:\n
\n- The study finds that HPV vaccination is highly cost-effective<\/strong> based on Mongolia\u2019s GDP per capita ($3,735 in 2018), as the ICER remains below 20% of GDP per capita<\/strong>.<\/li>\n<\/ul>\n<\/li>\n
- Vaccine Options<\/strong>:\n
\n- Quadrivalent vaccine (HPV4 – Gardasil)<\/strong>: Targets HPV types 6, 11, 16, and 18.<\/li>\n
- Bivalent vaccine (HPV2 – Cervarix)<\/strong>: Targets HPV types 16 and 18, with additional cross-protection against HPV 31 and 33.<\/li>\n
- Bivalent vaccine<\/strong> was found to be more cost-effective due to greater cross-protection.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
The researchers employed the UNIVAC model (version 1.4)<\/strong> to estimate the incremental costs, health outcomes, and economic impact<\/strong> of vaccination compared to no vaccination. The analysis focused on two vaccine options: quadrivalent (HPV4 – Gardasil)<\/strong>, which targets HPV types 6, 11, 16, and 18, and bivalent (HPV2 – Cervarix)<\/strong>, which targets HPV types 16 and 18 but also provides cross-protection against HPV 31 and 33. The study modeled vaccination for 9-year-old girls<\/strong> over a period of ten birth cohorts (2022\u20132031)<\/strong>, assuming a 93% coverage rate<\/strong>.<\/p>\nWhile the economic analysis strongly supports the introduction of HPV vaccination in Mongolia, there are practical challenges to implementation<\/strong>. The country does not qualify for Gavi co-financing<\/strong>, meaning that securing lower vaccine prices through manufacturer negotiations<\/strong> will be critical. Moreover, public acceptance remains a concern<\/strong>, as a previous HPV vaccination pilot program in 2012 was halted due to fears about vaccine safety. Another challenge is Mongolia\u2019s low cervical cancer screening rates<\/strong>, with only 30% of women of reproductive age having undergone screening at least once<\/strong>. This suggests that HPV vaccination should be integrated with efforts to improve screening and early detection programs<\/strong>.<\/p>\nTo strengthen the findings, the study conducted sensitivity analyses<\/strong> using Monte Carlo simulations (5,000 iterations)<\/strong> to test the robustness of the results under different assumptions. The most influential parameters affecting cost-effectiveness were vaccine price per dose, cervical cancer incidence rates, and vaccine delivery costs<\/strong>. The analysis confirmed that HPV vaccination remains cost-effective under a wide range of pricing and epidemiological scenarios<\/strong>.<\/p>\nIn conclusion, this study provides strong evidence that HPV vaccination is a highly cost-effective intervention for reducing cervical cancer in Mongolia<\/strong>. Despite funding and public perception challenges<\/strong>, implementing a national HPV immunization program for girls, particularly with the bivalent vaccine, would provide significant health benefits and reduce the cervical cancer burden<\/strong>. Policymakers should prioritize securing affordable vaccine pricing<\/strong> and integrating vaccination with improved cervical cancer screening efforts<\/strong> to maximize the impact of this intervention.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
As reported by the study titled “The Potential Cost-Effectiveness of HPV Vaccination Among Girls in Mongolia” , HPV vaccination has not been introduced nationally and Gavi co-financing support is not available in Mongolia. To inform introduction decision-making, study authors evaluated the potential cost-effectiveness of HPV vaccination among girls and young women in Mongolia. Key findings:…<\/p>\n","protected":false},"author":137,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":""},"categories":[],"tags":[118,3044],"document_type":[],"acf":[],"_links":{"self":[{"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/documents\/987756970"}],"collection":[{"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/documents"}],"about":[{"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/types\/documents"}],"author":[{"embeddable":true,"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/users\/137"}],"replies":[{"embeddable":true,"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/comments?post=987756970"}],"version-history":[{"count":4,"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/documents\/987756970\/revisions"}],"predecessor-version":[{"id":987758882,"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/documents\/987756970\/revisions\/987758882"}],"wp:attachment":[{"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/media?parent=987756970"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/categories?post=987756970"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/tags?post=987756970"},{"taxonomy":"document_type","embeddable":true,"href":"https:\/\/p4h.world\/en\/wp-json\/wp\/v2\/document_type?post=987756970"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}