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Priority setting is selecting interventions, among long-list of options, which can address the most important health needs of the population. However, selection of specific intervention to be included in the Essential Health Service Package or health insurance benefit packages; which intervention to provide for free, through cost-sharing or cost recovery; which intervention to scale-up or scale-down in the health sector plans is challenging without a clear guiding principle. The primary purpose of this protocol is to guide the prioritization of health interventions in the revision of Ethiopian essential health service package. In addition, the protocol can be used for appraisal of the health technology assessment (HTA) in Ethiopia or an other prioritiy-setting excersise in the health sector.