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Published in The Lancet Global Health, this comprehensive meta-regression analysis evaluates the cost-effectiveness of interventions for HIV/AIDS, malaria, syphilis, and tuberculosis across 128 countries, providing crucial insights for national decision-makers in health financing and social health protection. Drawing on extensive data from the Tufts University Cost-Effectiveness Registries, the study standardizes and maps incremental cost-effectiveness ratios (ICERs) for 25 interventions, predicting country-specific ICERs for 14 recommended interventions. The findings, presented in detailed league tables, reveal significant variations in intervention cost-effectiveness across countries, highlighting the importance of tailored resource allocation to maximize health outcomes and ensure efficient use of funds in Global Fund-eligible countries.