he document titled “Estimated Global and Regional Economic Burden of Genital Herpes Simplex Virus Infection among 15–49 Year-Olds in 2016,” authored by Nathorn Chaiyakunapruk, et. al., explores the substantial global economic burden of genital herpes simplex virus (HSV) infections. The study provides a comprehensive analysis of the costs associated with HSV-2 and HSV-1 infections, focusing on the financial implications for individuals with genital ulcer disease, neonatal herpes, and HIV infections attributable to HSV-2. Through a societal perspective, the authors estimate the global and regional economic impact of these infections, emphasising the need for accelerated HSV prevention and vaccine development efforts.