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The article titled ‘The Future of Health Technology Assessment in Low- and Middle-Income Countries’, published in Health Systems and Reform, explores the evolving role of Health Technology Assessment (HTA) in low- and middle-income countries (LMICs). As these countries strive for universal health coverage, HTA has proven essential in helping prioritize healthcare interventions, offering substantial cost savings, as demonstrated in countries like Thailand and Brazil. However, challenges persist, including limited capacity to conduct HTA and incorporate its findings into policy decisions. This research highlights how LMICs can enhance their use of HTA by embracing innovative methodologies, localizing aid efforts, and fostering regional collaboration, ultimately aiming to optimize healthcare spending, improve outcomes, and strengthen global health security.