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In their article titled “The Role of HTA for Essential Health Benefit Package Design in Low or Middle-Income Countries,” Ole F. Norheim and David A. Watkins examine how Health Technology Assessment (HTA) can contribute to the design of Health Benefit Packages (HBPs) aimed at achieving Universal Health Coverage (UHC) in low- and middle-income countries (LMICs). Published online on November 10, 2023, the commentary explores the distinction between HTA, which assesses individual healthcare interventions, and HBP design, which focuses on creating comprehensive service packages based on population health needs and resource availability. The authors highlight the challenges faced by LMICs, such as limited local data and technical capacity, and propose a hybrid approach that integrates HTA with HBP design. This method involves setting differentiated cost-effectiveness thresholds for various healthcare platforms and programs, facilitating evidence-informed priority-setting that aligns with organizational, ethical, and implementation considerations. The article underscores the importance of strong institutions and academic support in enhancing priority-setting processes for equitable and sustainable healthcare solutions.