Rare diseases in Hainan Province pose a significant economic burden, with a rising prevalence and limited data available. A study from 2019 to 2023 found that 83.01% of the 4,975 diagnosed patients were insured, yet total economic costs escalated from 34.26 million CNY to 64.74 million CNY, primarily driven by hospitalisation expenses. The findings underline the need for targeted policy interventions and further research to better estimate the economic impact of rare diseases in the region.
