This study assessed the annual out-of-pocket (OOP) costs of cancer care for patients in Bangladesh, their coping mechanisms, and the financial distress they experienced. Using data from three hospitals, researchers estimated an average annual OOP cost of US$ 6,504 per patient—over twice the average household income—with 90% of families reporting financial distress. Higher OOP costs were linked to advanced cancer stage, comorbidities, lack of elderly household members, and seeking treatment abroad.